Types Of The Immune System Essays
The bacterium that caused her infection was Clostridium difficile. The bacteria already lived in her colon, but it was kept under control by other bacteria in the colon.
C. difficile gets past innate immune barriers by secreting toxins A and B (Solomon). Toxins A and B attack intestinal epithelial cells, which causes a proinflammatory cytokine release (Solomon). Proinflammatory cytokine release causes neutrophil infiltration, which causes excessive inflammation and tissue damage (Solomon). Also, Toxin A, or TcdA, attaches to monocytes and promotes apoptosis (i.e., programmed cell death); monocytes are major components of the immune system (Solomon).
The bacterium started causing trouble after her 10-day prescription of antibiotics. The antibiotics wiped out the bacteria that kept C. difficile under control and thus, C. difficile began to proliferate and caused her terrible infection
C. difficile causes disease through quorum signaling and the subsequent release of toxins A and B (Darkoh et al.). The pathogenic version of C. difficile makes these…